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Critical roles in maintaining redox are exerted by antioxidant systems, including the thioredoxin/peroxiredoxin systems and the nuclear erythroid related transcription factor 2 (Nrf2), which regulates the expression of detoxification proteins such as Kelch-like ECH-associated protein 1 (Keap1) [181]
This focused approach makes AOD-9604 a potentially safer experimental option compared to broader-acting treatments
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doi:10.1073/pnas.62.2.461
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